吴江维， 博士，教授

出生年月：1980. 03. 16

籍贯：陕西省蓝田县 

电话：18091873865 Email: wujiangwei@nwafu.edu.cn

教育和工作背景

2016/09-至今 taptap国际服苹果版， 教授

2012/04-2016/04，加拿大蒙特利尔大学，博士后

2011/07-2012/03，加拿大蒙特利尔大学，研究助理

2008/09-2011/05，加拿大蒙特利尔大学，联合培养博士

2006/09-2011/07，taptap国际服苹果版，动物科技学院，博士

2003/09-2006/07，taptap国际服苹果版，动物科技学院，硕士

1999/09-2003/07，taptap国际服苹果版，动物科技学院，学士

研究方向及成果

长期从事生猪育种及猪医学价值开发工作，采用基因编辑和细胞生物学等技术 研究调控动物肌肉生长发育和脂质沉积的分子机制，深度挖掘关键调控基因。推 动建立陕西省猪种质创新中心与育种基地，带领团队培育优质高繁新品种秦川黑 猪并实现千万元的转化；搭建了基因编辑猪产学研协同创新平台，推动我国基因 编辑大动物模型创制跃居世界前列，为猪分子育种和生物医学研究提供理论基础 和科技支撑。获批国家“青年人才项目”、两项国家自然基金面上项目及十四五 国家重点研发计划等课题。相关成果以通讯作者发表在 Cell Metabolism（亮 点文章）、Nature Communications、Advanced Science 及 The EMBO Journal 等国际学术期刊，受到科技部重点关注与报道。荣获陕西省中青年科技 创新领军人才、陕西青年科技标兵、陕西青年科技奖等荣誉称号。

代表性论文（#相同贡献 *通讯作者）

1. Zhe Zhang#, Xiang Kai Leng#, Yuan Yuan Zhai#, Xiao Zhang, Zhi Wei Sun, Jun Ying Xiao, Jun Feng Lu, Kun Liu, Bo Xia, Qi Gao, Miao Jia, Cheng Qi Xu, Yi Na Jiang, Xiao Gang Zhang*, Kai Shan Tao*, Jiang Wei Wu*, Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress, Nature communications, 2024 Mar 8. (Impact Factor: 16.6)

2. Jun Feng Lu#, Meng Qing Zhu#, Bo Xia#, Na Na Zhang#, Xiao Peng Liu, Huan Liu, Rui Xin Zhang, Jun Ying Xiao, Hui Yang, Ying Qi Zhang, Xiao Miao Li*, Jiang Wei Wu*. GDF15 is a major determinant of ketogenic diet-induced weight loss. Cell Metabolism. 2023 Dec 5. Impact Factor: 29.0) 

3. Huan Liu#, Dengke Pan#, Pu Li#, Dandan Wang#, Bo Xia, Ruixin Zhang, Junfeng Lu, Xiangyang Xing, Jiaxiang Du, Xiao Zhang, Long Jin, Lin Jiang*, Linong Yao*, Mingzhou Li*, Jiangwei Wu*. Loss of ZBED6 Protects Against Sepsis-Induced Muscle Atrophy by Upregulating DOCK3-Mediated RAC1/PI3K/AKT Signaling Pathway in Pigs. Advanced Science. 2023 Aug 7. (Impact Factor: 15.1)

4. Rui Xin Zhang#, Yuan Yuan Zhai#, Rong Rong Ding#, Jia He Huang, Xiao Chen Shi, Huan Liu, Xiao Peng Liu, Jian Feng Zhang, Jun Feng Lu, Zhe Zhang, Xiang Kai Leng, De Fu Li, Jun Ying Xiao, Bo Xia, Jiang Wei Wu*, FNDC1 is a myokine that promotes myogenesis and muscle regeneration, The EMBO Journal, 2025, Jan. (Impact Factor: 9.5)

5. Luxi Chen#, Jing Li#, Renqiang Yuan#, Yujie Wang#, Jiaman Zhang#, Yu Lin#, Lina Wang, Xingxing Zhu, Wei Zhu, Jingyi Bai, Fanli Kong, Bo Zeng, Lu Lu, Jideng Ma, Keren Long, Long Jin, Zhiqing Huang, Jinlong Huo, Yiren Gu, Danyang Wang, Delin Mo, Diyan Li, Qianzi Tang, Xuewei Li, Jiangwei Wu*, Yaosheng Chen*, Mingzhou Li*. Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver. Cell Discovery. 2022 Jun 14. (Impact Factor: 33.5)

6. Xiao Chen Shi#, Bo Xia#, Jian Feng Zhang, Rui Xin Zhang, Dan Yang Zhang, Huan Liu, Bao Cai Xie, Yong Liang Wang*, Jiang Wei Wu*. Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β. PLOS Biology. 2022 Apr 27. (Impact Factor: 9.8) 

7. Jun Feng Lu#, Meng Qing Zhu#, Bao Cai Xie, Xiao Chen Shi, Huan Liu, Rui Xin Zhang, Bo Xia, Jiang Wei Wu*. Camptothecin effectively treats obesity in mice through GDF15 induction. PLOS Biology. 2022 Feb 24. (Impact Factor: 9.8) 

8. Bo Xia#, Xiao Chen Shi#, Bao Cai Xie#, Meng Qing Zhu, Yan Chen, Xin Yi Chu, Guo He Cai, Min Liu, Shi Zhen Yang, Grant A. Mitchell, Wei Jun Pang*, Jiang Wei Wu*. Urolithin A exerts antiobesity effects through enhancing adipose tissuethermogenesis in mice. PLOS Biology. 2020 Mar 27. (Impact Factor: 9.8) 

9. Yongliang Wang, Huan Liu, Ruixin Zhang, Yuyao Xiang, Junfeng Lu, Bo Xia*, Liang Peng*, Jiangwei Wu*. AdipoRon exerts opposing effects on insulin sensitivity via fibroblast growth factor 21–mediated time-dependent mechanisms. Journal of Biological Chemistry. 2022 Jan 25. (Impact Factor: 4.8) 

10. Dandan Wang#, Denke Pan#, Baocai Xie#, Shengnan Wang, Xiangyang Xing, Xuexue Liu, Yuehui Ma, Leif Andersson, Jiangwei Wu*, Lin Jiang*. Porcine ZBED6 regulates growth of skeletal muscle and internal organs via multiple targets. PLOS Genetics. 2021 Oct 28. (Impact Factor: 4.5) 

11. Bao Cai Xie#, Xiao Chen Shi#, Yan Li#, Bo Xia, Jia Zhou, Minjie Du, Xiangyang Xing, Liang Bai, Enqi Liu, Fernando Alvarez, Long Jin, Shaoping Deng, Grant A. Mitchell, Dengke Pan*, Mingzhou Li*, Jiangwei Wu*. Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans. PLOS Genetics. 2021 Nov 11. (Impact Factor: 4.5)

12. Jiang Wei Wu*#, Christoph Preuss#, Shu Pei Wang, Hao Yang, Bo Ji, Gregory W. Carter, Rebecca Gladdy, Gregor Andelfinger*, Grant A. Mitchell*. Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice. PLOS Genetics. 2017 May 1. (Impact Factor: 4.5)

13. Bo Xia#, Guo He Cai#, Hao Yang, Shu Pei Wang, Grant A. Mitchell*, Jiang Wei Wu*, Adipose tissue deficiency of hormone-sensitive lipase causes fatty liver in mice. PLOS Genetics. 2017 Dec 12. (Impact Factor: 4.5)

14. Jiang Wei Wu, Hao Yang, Grant A. Mitchell*. Potential Mechanism Underlying the PNPLA3I148M-Hepatic Steatosis Connection. Hepatology. 2015 Jun 19. (Impact Factor: 13.5)

15. Jiang Wei Wu, Shu Pei Wang, Fernando Alvarez, Stéphanie Casavant, Nicolas Gauthier, Lynda Abed, Krishnakant G. Soni, Gongshe Yang*, Grant A. Mitchell*. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology. 2011 Apr 04. (Impact Factor: 13.5) 

16. Baocai Xie#, Dengke Pan#, Huan Liu, Min Liu, Xiaochen Shi, Xinyi Chu, Junfeng Lu, Mengqing Zhu, Bo Xia, Jiangwei Wu*. Diosmetin Protects Against Obesity and Metabolic Dysfunctions Through Activation of Adipose Estrogen Receptors in Mice. Molecular Nutrition & Food Research. 2021 Jul 05. (Impact Factor: 5.2) 

17. Jianfeng Zhang#, Jiangwei Wu#, Xiaochen Shi, Defu Li, Shizhen Yang, Ruixin Zhang, Bo Xia, Gongshe Yang*. A Propolis-Derived Small Molecule Tectochrysin Ameliorates Type 2 Diabetes in Mice by Activating Insulin Receptor β. Molecular Nutrition & Food Research. 2023 October 27. (Impact Factor: 5.2) 

18. Yuyao Xiang#, Ruolan Huang#, Yongliang Wang#, Shanshan Han#, Xiaochen Qin#,Zhenzhen Li, Xu Wang, Yuqing Han, Tao Wang, Bo Xia, Jiangwei Wu, Gongshe Yang*. Protocatechuic acid ameliorates high fat diet-induced obesity and insulin resistance in mice. Molecular Nutrition & Food Research. 2023 October 14. (Impact Factor: 5.2)

19. Xin Yi Chu#, Cong Cong Zhang#, Rui Xin Zhang, Jian Feng Zhang, Bo Xia, Jiang Wei Wu*. Identification of Dacinostat as a potential anti-obesity compound through transcriptional activation of adipose thermogenesis in mice. BBA-Molecular Basis of Disease. 2021 May 15. (Impact Factor: 6.633) 

20. Xin Zhang, Doudou Xu, Meixia Chen, Yubo Wang, Linjuan He, Lu Wang, Jiangwei Wu, Jingdong Yin*. Impacts of Selected Dietary Nutrient Intakes on Skeletal Muscle Insulin Sensitivity and Applications to Early Prevention of Type 2 Diabetes. Advances in Nutrition. 2021 Jan 8. (Impact Factor: 9.3) 

21. Jun Feng Lu#, Meng Qing Zhu#, Heng Zhang, Hao Liu, Bo Xia, Yong Liang Wang, Xin’e Shi, Liang Peng*, Jiang Wei Wu*. Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high-fat diet-fed mice. The FASEB Journal. 2020 Jul 30. (Impact Factor: 5.834) 

22. Yan Chen#, Guo He Cai#, Bo Xia, Xin Wang, Cong Cong Zhang, Bao Cai Xie, Xiao Chen Shi, Huan Liu, Jun Feng Lu, Rui Xin Zhang, Meng Qing Zhu, Min Liu, Shi Zhen Yang, Dan Yang Zhang, Xin Yi Chu, Rajwali Khan, Yong Liang Wang, Jiang Wei Wu*. Mitochondrial aconitase controls adipogenesis through mediation of cellular ATP production. The FASEB Journal. 2020 Mar 24. (Impact Factor: 5.834) 

23. Xin Yi Chu, Shi Zhen Yang, Meng Qing Zhu, Dan Yang Zhang, Xiao Chen Shi, Bo Xia, Ye Yuan, Min Liu, Jiang Wei Wu*. Isorhapontigenin Improves Diabetes in Mice via Regulating the Activity and Stability of PPARgamma in Adipocytes. Journal of Agricultural and Food Chemistry. 2020 Mar 16. (Impact Factor: 6.1) 

24. Xin Wang#, Min Liu#, Guo He Cai, Yan Chen, Xiao Chen Shi, Cong Cong Zhang, Bo Xia, Bao Cai Xie, Huan Liu, Rui Xin Zhang, Jun Feng Lu, Meng Qing Zhu, Shi Zhen Yang, Xin Yi Chu, Dan Yang Zhang, Yong Liang Wang, Jiang Wei Wu*. A Potential Nutraceutical Candidate Lactucin Inhibits Adipogenesis through Downregulation of JAK2/STAT3 Signaling Pathway-Mediated Mitotic Clonal Expansion. Cells. 2020 Jan 31. (Impact Factor: 6.0) 

25. Xiao Zhang, Cong Cong Zhang, Hao Yang, Krishnakant G. Soni, Shu Pei Wang, Grant A. Mitchell*, Jiang Wei Wu*. An Epistatic Interaction between Pnpla2 and Lipe Reveals New Pathways of Adipose Tissue Lipolysis. Cells. 2019 Apr 29. (Impact Factor: 6.0) 

26. Hao Yang, Jiang Wei Wu, Shu Pei Wang, Ilenia Severi, Loris Sartini, Norma Frizzell, Saverio Cinti, Gongshe Yang*, Grant A. Mitchell*. Adipose-Specific Deficiency ofFumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance. Diabetes. 2012 Dec. (Impact Factor: 9.79) 

27. Jiang Wei Wu, Hao Yang, Shu Pei Wang, Krishnakant G. Soni, Catherine Brunel-Guitton & Grant A. Mitchell*. Inborn errors of cytoplasmic triglyceride metabolism. Journal of Inherited Metabolic Disease. 2014 Oct 10. (Impact Factor: 4.2) 

28. Jiang Wei Wu, Shu Pei Wang, Stéphanie Casavant, Alain Moreau, Gong She Yang, Grant A. Mitchell*. Fasting Energy Homeostasis in Mice with Adipose Deficiency of Desnutrin/Adipose Triglyceride Lipase. Endocrinology. 2012 May 01. (Impact Factor: 4.8)

专利

1. 吴江维;马俊林;冷祥恺;陈家豪;李孟珂 一种妊娠期家畜用引导装置，专利号：ZL202320816635.3（已授权）

2. 吴江维;马俊林;李孟珂;裴浩宇;冷祥恺 一种攻击性强的家畜用引导装置，专 利号：ZL202320816678.1（已授权）

3. 马俊林;吴江维;裴浩宇;陈家豪;冷祥恺;李德富 一种家畜引导装置，专利号：ZL202320824403.2（已授权）

主持和参与项目

1. 国家自然科学基金面上项目，基于内质网应激信号通路探究 ASGR1 基因缺 失导致肝损伤的机制，2024-2027, (主持，经费 50 万)

2. 十四五国家重点研发计划，猪高产优质高效性状形成的调控网络及多基因互 作机制，2021-2026, (课题负责人，经费 2496 万)

3. 科技创新 2030—重大项目子课题，猪优质高产性状功能基因和变异位点鉴 定，2023-2025, (子课题负责人，经费 80 万) 

4. 国家自然科学基金面上项目，利用 CRISPR-Cas9 技术构建 ASGR1 基因敲 除猪作为人类动脉粥样硬化疾病模型的研究，2021-2024, (主持，经费 58万) 

5. 陕西省创新能力支撑计划项目，肌肉生物学与猪遗传改良创新团队，2023-2025, (主持，经费 100 万)

6. 十三五国家重点研发计划，日粮组成与饲养体制对畜禽健康优质肉形成的调 控及机制，2018-2020, (子课题负责人，经费 55.2 万) 

7. 陕西省“**********计划”创新全职项目，2017-2022, (主持，经费 100 万) 

8. taptap国际服苹果版科研启动经费，脂代谢在动物肌内脂肪沉积和肌肉发育中 的作用及其调控机理，2016-2021, (主持，经费 600 万) 

9. 陕西省重点研究计划，转录因子 ZBED6 在调控猪骨骼肌生长发育中的作用 及其机制研究，2020-2021, (主持，经费 10 万) 

10. 生命科学教学科研平台配套设备购置项目，2021-2022, (经费 230 万) 11. 中 央 高 校 基 本 科 研 业 务 费 专 项 资 金 项 目 - 科 技 创 新 专 项 项 目 ，2018.1-2018.12, (经费 8万）